An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement

• Main Authors: Shane G. Poplawski (Author), Krassimira A. Garbett (Author), Rebekah L. McMahan (Author), Holly B. Kordasiewicz (Author), Hien Zhao (Author), Andrew J. Kennedy (Author), Slavina B. Goleva (Author), Teresa H. Sanders (Author), S. Timothy Motley (Author), Eric E. Swayze (Author), David J. Ecker (Author), J. David Sweatt (Author), Todd P. Michael (Author), Celeste B. Greer (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Knockout of the memory suppressor gene histone deacetylase 2 (Hdac2) in mice elicits cognitive enhancement, and drugs that block HDAC2 have potential as therapeutics for disorders affecting memory. Currently available HDAC2 catalytic activity inhibitors are not fully isoform specific and have short...