The Evolving Paradigm of Antibody-Drug Conjugates Targeting the ErbB/HER Family of Receptor Tyrosine Kinases

• Main Authors: Peyton High (Author), Cara Guernsey (Author), Shraddha Subramanian (Author), Joan Jacob (Author), Kendra S. Carmon (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2024-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Current therapies targeting the human epidermal growth factor receptor (HER) family, including monoclonal antibodies (mAbs) and tyrosine kinase inhibitors (TKIs), are limited by drug resistance and systemic toxicities. Antibody-drug conjugates (ADCs) are one of the most rapidly expanding classes of...