6-Sulfatoxymelatonin predicts treatment response to fluoxetine in major depressive disorder

• Main Authors: Juliana Jury Freitas (Author), Nicóli Bertuol Xavier (Author), André Comiran Tonon (Author), Alicia Carissimi (Author), Leandro Timm Pizutti (Author), Carlos Augusto Vieira Ilgenfritz (Author), Regina Pekelmann Markus (Author), Maria Paz Hidalgo (Author)
• Format: Book
• Published: SAGE Publishing, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: To date, no biomarker has been able to predict antidepressant response at an early blockade of norepinephrine or serotonin uptake. The transient nocturnal increase in plasma melatonin levels is upregulated by blocking these uptakes. The aim of this study was to test whether fluoxetine in...