Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

• मुख्य लेखकों: Zhen Chen (लेखक), Wakana Mori (लेखक), Jian Rong (लेखक), Michael A. Schafroth (लेखक), Tuo Shao (लेखक), Richard S. Van (लेखक), Daisuke Ogasawara (लेखक), Tomoteru Yamasaki (लेखक), Atsuto Hiraishi (लेखक), Akiko Hatori (लेखक), Jiahui Chen (लेखक), Yiding Zhang (लेखक), Kuan Hu (लेखक), Masayuki Fujinaga (लेखक), Jiyun Sun (लेखक), Qingzhen Yu (लेखक), Thomas L. Collier (लेखक), Yihan Shao (लेखक), Benjamin F. Cravatt (लेखक), Lee Josephson (लेखक), Ming-Rong Zhang (लेखक), Steven H. Liang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been associated with multiple CNS disorders and symptom...