Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

• Main Authors: Zhen Chen (Author), Wakana Mori (Author), Jian Rong (Author), Michael A. Schafroth (Author), Tuo Shao (Author), Richard S. Van (Author), Daisuke Ogasawara (Author), Tomoteru Yamasaki (Author), Atsuto Hiraishi (Author), Akiko Hatori (Author), Jiahui Chen (Author), Yiding Zhang (Author), Kuan Hu (Author), Masayuki Fujinaga (Author), Jiyun Sun (Author), Qingzhen Yu (Author), Thomas L. Collier (Author), Yihan Shao (Author), Benjamin F. Cravatt (Author), Lee Josephson (Author), Ming-Rong Zhang (Author), Steven H. Liang (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been associated with multiple CNS disorders and symptom...