A targeted covalent inhibitor of p97 with proteome-wide selectivity

• Asıl Yazarlar: Zi Ye (Yazar), Ke Wang (Yazar), Lianguo Chen (Yazar), Xiaofeng Jin (Yazar), Hao Chen (Yazar), Guanghui Tang (Yazar), Shao Q. Yao (Yazar), Zhiqiang Feng (Yazar), Chong-Jing Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2022-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

A resurging interest in targeted covalent inhibitors (TCIs) focus on compounds capable of irreversibly reacting with nucleophilic amino acids in a druggable target. p97 is an emerging protein target for cancer therapy, viral infections and neurodegenerative diseases. Extensive efforts were devoted t...