Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

• প্রধান লেখক: Yuji Hori (লেখক), Ken Ohmine (লেখক), Hitoshi Katada (লেখক), Yuki Noguchi (লেখক), Kazuki Sato (লেখক), Takeru Nambu (লেখক), Lam Runyi Adeline (লেখক), Gan Siok Wan (লেখক), Kenta Haraya (লেখক), Kazuhisa Ozeki (লেখক), Masahiko Nanami (লেখক), Tatsuhiko Tachibana (লেখক), Zenjiro Sampei (লেখক), Taichi Kuramochi (লেখক), Junichi Nezu (লেখক), Kunihiro Hattori (লেখক), Tomoyuki Igawa (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen. This is because antigen degradation is reduced by the formation of antigen-antibody immune complexes, which escape from lysosomal deg...