Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

• Main Authors: Yuji Hori (Author), Ken Ohmine (Author), Hitoshi Katada (Author), Yuki Noguchi (Author), Kazuki Sato (Author), Takeru Nambu (Author), Lam Runyi Adeline (Author), Gan Siok Wan (Author), Kenta Haraya (Author), Kazuhisa Ozeki (Author), Masahiko Nanami (Author), Tatsuhiko Tachibana (Author), Zenjiro Sampei (Author), Taichi Kuramochi (Author), Junichi Nezu (Author), Kunihiro Hattori (Author), Tomoyuki Igawa (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen. This is because antigen degradation is reduced by the formation of antigen-antibody immune complexes, which escape from lysosomal deg...