Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

• मुख्य लेखकों: Songjiang Yin (लेखक), Li Zhang (लेखक), Liang Ding (लेखक), Zhengquan Huang (लेखक), Bo Xu (लेखक), XiaoChen Li (लेखक), Peimin Wang (लेखक), Jun Mao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2018-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associa...