Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

• Hauptverfasser: Songjiang Yin (Verfasst von), Li Zhang (Verfasst von), Liang Ding (Verfasst von), Zhengquan Huang (Verfasst von), Bo Xu (Verfasst von), XiaoChen Li (Verfasst von), Peimin Wang (Verfasst von), Jun Mao (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2018-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+), also known as a cellular second messenger. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associa...