In silico discovery of repetitive elements as key sequence determinants of 3D genome folding

• Główni autorzy: Laura M. Gunsalus (Autor), Michael J. Keiser (Autor), Katherine S. Pollard (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Summary: Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome wide. We developed a deep-learning strategy to quantify the effect of any insertion, deletion, or...