Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

• Main Authors: Piotr A. Mroz (Author), Brian Finan (Author), Vasily Gelfanov (Author), Bin Yang (Author), Matthias H. Tschöp (Author), Richard D. DiMarchi (Author), Diego Perez-Tilve (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. Methods: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...