Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

• Κύριοι συγγραφείς: Piotr A. Mroz (Συγγραφέας), Brian Finan (Συγγραφέας), Vasily Gelfanov (Συγγραφέας), Bin Yang (Συγγραφέας), Matthias H. Tschöp (Συγγραφέας), Richard D. DiMarchi (Συγγραφέας), Diego Perez-Tilve (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2019-02-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Objective: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. Methods: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...