Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

• Asıl Yazarlar: Piotr A. Mroz (Yazar), Brian Finan (Yazar), Vasily Gelfanov (Yazar), Bin Yang (Yazar), Matthias H. Tschöp (Yazar), Richard D. DiMarchi (Yazar), Diego Perez-Tilve (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2019-02-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. Methods: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...