E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer

• Main Authors: Min Xu (Author), Shaosen Zhang (Author), Lin Jia (Author), Shan Wang (Author), Jie Liu (Author), Xuhui Ma (Author), Chunying Wang (Author), Yan Fu (Author), Yongzhang Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endostatin recently was reported by our laboratory to possess ATPase activity that is indispensable for its anti-angiogenesis and anti-tumor effects. An engineered endostatin, E-M, which owns higher ATPase activity exhibits stronger inhibitory effects on angiogenesis. Tumor-associated macrophages (T...