Metabolic model of necrotizing enterocolitis in the premature newborn gut resulting from enteric dysbiosis

• Main Authors: Giorgio Casaburi (Author), Jingjing Wei (Author), Sufyan Kazi (Author), Junlin Liu (Author), Kewei Wang (Author), Guo-Zhong Tao (Author), Po-Yu Lin (Author), James C. Y. Dunn (Author), Bethany M. Henrick (Author), Steven A. Frese (Author), Karl G. Sylvester (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necrotizing enterocolitis (NEC) is a leading cause of premature newborn morbidity and mortality. The clinical features of NEC consistently include prematurity, gut dysbiosis and enteral inflammation, yet the pathogenesis remains obscure. Herein we combine metagenomics and targeted metabolomics, with...