Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice

• Main Authors: Wanze Tang (Author), Zhen Ding (Author), Huanqing Gao (Author), Qinnan Yan (Author), Jingping Liu (Author), Yingying Han (Author), Xiaoting Hou (Author), Zhengwei Liu (Author), Litong Chen (Author), Dazhi Yang (Author), Guixing Ma (Author), Huiling Cao (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoporosis (OP) is a systemic skeletal disease that primarily affects the elderly population, which greatly increases the risk of fractures. Here we report that Kindlin-2 expression in adipose tissue increases during aging and high-fat diet fed and is accompanied by decreased bone mass. Kindlin-2...