High immune cytolytic activity in tumor‐free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

• Main Authors: Xiaolian Gu (Author), Linda Boldrup (Author), Philip J Coates (Author), Robin Fahraeus (Author), Lixiao Wang (Author), Torben Wilms (Author), Lena Norberg‐Spaak (Author), Nicola Sgaramella (Author), Karin Nylander (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investi...