Modeling a cataract disorder in mice with prime editing

• Main Authors: Jianxiang Lin (Author), Xingchen Liu (Author), Zongyang Lu (Author), Shisheng Huang (Author), Susu Wu (Author), Wenxia Yu (Author), Yao Liu (Author), Xiaoguo Zheng (Author), Xingxu Huang (Author), Qiang Sun (Author), Yunbo Qiao (Author), Zhen Liu (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here, we successfully generate a mouse model with a cat...