Modeling a cataract disorder in mice with prime editing

• Үндсэн зохиолчид: Jianxiang Lin (Зохиогч), Xingchen Liu (Зохиогч), Zongyang Lu (Зохиогч), Shisheng Huang (Зохиогч), Susu Wu (Зохиогч), Wenxia Yu (Зохиогч), Yao Liu (Зохиогч), Xiaoguo Zheng (Зохиогч), Xingxu Huang (Зохиогч), Qiang Sun (Зохиогч), Yunbo Qiao (Зохиогч), Zhen Liu (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2021-09-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here, we successfully generate a mouse model with a cat...