Direct spectrofluorimetric methods as alternatives to compendial ones used for the quality control of biopharmaceuticals: development, validation and application

• Main Authors: Thallis Martins Souza (Author), Robert da Silva Angelino (Author), Larissa Manhães Ornella (Author), Eduardo dos Santos Ribeiro (Author), Simone Ferreira Rodrigues Fernandes (Author)
• Format: Book
• Published: Universidade de São Paulo, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A simple, rapid, precise, accurate and sustainable spectrofluorimetric method (SFM) was developed, validated and applied for the determination of 4-aminobenzoic acid and aromatic amino acids (phenylalanine, tryptophan and tyrosine). These compounds are used in biopharmaceutical formulations...