Downregulation of miR-503 in Activated Kidney Fibroblasts Disinhibits KCNN4 in an in Vitro Model of Kidney Fibrosis

• Главные авторы: Christoph Mann (Автор), Brajesh Pratap Kaistha (Автор), Michael Kacik (Автор), Thorsten Stiewe (Автор), Joachim Hoyer (Автор)
• Формат: ‌
• Опубликовано: Karger Publishers, 2019-02-01T00:00:00Z.
• Предметы: article
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Background/Aims: Activated fibroblasts are key controllers of extracellular matrix turnover in kidney fibrosis, the pathophysiological end stage of chronic kidney disease. The proliferation of activated fibroblasts depends on the expression of the calcium-dependent potassium channel KCNN4. Expressio...