CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway

• Main Authors: Meng-Yao Sun (Author), Su-Juan Wang (Author), Xiao-Qin Li (Author), Yu-Li Shen (Author), Jian-Rao Lu (Author), Xin-Hui Tian (Author), Khalid Rahman (Author), Li-Jun Zhang (Author), Hua Nian (Author), Hong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study the role of CXCL6 in diabetic nephropathy (DN) was investigated. It was found to be overexpression in DN patients and DN rat model. And the expression of fibrosis-related cytokines was consistent with the expression of CXCL6. High glucose significantly increased the proliferation of ra...