A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models

• Main Authors: Ryusuke Sugita (Author), Kazufumi Kubota (Author), Kotaro Sugimoto (Author), Yuki Tachida (Author), Takahiro Shibayama (Author), Toshihiro Kiho (Author), Katsuhiro Kawakami (Author), Kohei Shimada (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostaglandin E2 (PGE2), one of the terminal products in the cyclooxygenase pathway, plays an important role in various inflammatory responses. To determine whether selective inhibition of PGE2 may relieve these inflammatory symptoms, we synthesized a selective PGE2 synthesis inhibitor, compound A [...