Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway

• Main Authors: Yong Wang (Author), Shouzhen Chen (Author), Shuna Sun (Author), Guangyi Liu (Author), Lipeng Chen (Author), Yangyang Xia (Author), Jianfeng Cui (Author), Wenfu Wang (Author), Xuewen Jiang (Author), Lei Zhang (Author), Yaofeng Zhu (Author), Yongxin Zou (Author), Benkang Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wogonin, an active component derived from Scutellaria baicalensis, has shown anti-tumor activities in several malignancies. However, the roles of wogonin in RCC cells remain elusive. Here, we explored the effects of wogonin on RCC cells and the underlying mechanisms. We found that wogonin showed sig...