Predominantly Pro-Inflammatory Phenotype with Mixed M1/M2 Polarization of Peripheral Blood Classical Monocytes and Monocyte-Derived Macrophages among Patients with Excessive Ethanol Intake

• Main Authors: María Fernández-Regueras (Author), Cristina Carbonell (Author), Daniel Salete-Granado (Author), Juan-Luis García (Author), Marcos Gragera (Author), María-Ángeles (Author), Francisco-Javier (Author), Andrea Mayado (Author), Jorge-Luis Torres (Author), Luis-Antonio Corchete (Author), Ricardo Usategui-Martín (Author), Elena Bueno-Martínez (Author), Maura Rojas-Pirela (Author), Guadalupe Sabio (Author), Rogelio González-Sarmiento (Author), Alberto Orfao (Author), Francisco-Javier Laso (Author), Julia Almeida (Author), Miguel Marcos (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive alcohol consumption impairs the immune system, induces oxidative stress, and triggers the activation of peripheral blood (PB) monocytes, thereby contributing to alcoholic liver disease (ALD). We analyzed the M1/M2 phenotypes of circulating classical monocytes and macrophage-derived monocyt...