Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-l-lysine dendrimer as a gene delivery system

• Egile Nagusiak: Jianmin Shen (Egilea), Jing Chen (Egilea), Jingbo Ma (Egilea), Linlan Fan (Egilea), Xiaoli Zhang (Egilea), Ting Yue (Egilea), Yaping Yan (Egilea), Yuhang Zhang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2020-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Antisense oligodeoxynucleotide (ASODN) can directly interfere a series of biological events of the target RNA derived from tumor cells through Watson-Crick base pairing, in turn, plays antitumor therapeutic roles. In the study, a novel HIF-1α ASODN-loaded nanocomposite was formulated to efficiently...