Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA

• Główni autorzy: Sergio Linares-Fernández (Autor), Julien Moreno (Autor), Elise Lambert (Autor), Perrine Mercier-Gouy (Autor), Laetitia Vachez (Autor), Bernard Verrier (Autor), Jean-Yves Exposito (Autor)
• Format: Książka
• Wydane: Elsevier, 2021-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

mRNA is a blooming technology for vaccination and has gained global attention during the SARS-CoV-2 pandemic. However, the recent clinical trials have highlighted increased reactogenicity when using high mRNA doses. Intending to increase the potency of mRNA therapeutics and to decrease the therapeut...