Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma

• Главные авторы: Feifei Qin (Автор), Yali Wang (Автор), Xian Jiang (Автор), Yujia Wang (Автор), Nan Zhang (Автор), Xiang Wen (Автор), Lian Wang (Автор), Qinglin Jiang (Автор), Gu He (Автор)
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• Опубликовано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предметы: article
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Overexpression of heat shock protein 90 (Hsp90) is common in various types of cancer. In cutaneous melanoma, a cancer with one of the high levels of Hsp90 overexpression, such expression was correlated with a panel of protein kinases, thus offering an opportunity to identify Hsp90-based multi-kinase...