Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells.

• Main Authors: Pei Xu (Author), Junling Gao (Author), Chao Shan (Author), Tiffany J Dunn (Author), Xuping Xie (Author), Hongjie Xia (Author), Jing Zou (Author), Beatriz H Thames (Author), Amulya Sajja (Author), Yongjia Yu (Author), Alexander N Freiberg (Author), Nikos Vasilakis (Author), Pei-Yong Shi (Author), Scott C Weaver (Author), Ping Wu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study...