Nanothin Conformal Coating with Poly(N-vinylpyrrolidone) and Tannic Acid (PVPON/TA) Preserves Murine and Human Pancreatic Islets Function

• Main Authors: Kateryna Polishevska (Author), Sandra Kelly (Author), Purushothaman Kuppan (Author), Karen L. Seeberger (Author), Saloni Aggarwal (Author), Joy Paramor (Author), Larry D. Unsworth (Author), Hubert M. Tse (Author), Gregory S. Korbutt (Author), Andrew R. Pepper (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulation strategies can reduce the inherent adaptive im...