Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment

• Main Authors: Pedro M Costa (Author), Ana L Cardoso (Author), Liliana S Mendonça (Author), Angelo Serani (Author), Carlos Custódia (Author), Mariana Conceição (Author), Sérgio Simões (Author), João N Moreira (Author), Luís Pereira de Almeida (Author), Maria C Pedroso de Lima (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was cov...