The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

• Main Authors: Arias-Vásquez Alejandro (Author), Oulhaj Abderrahim (Author), Mateo Ignacio (Author), Kölsch Heike (Author), Heun Reinhard (Author), Gwilliam Rhian (Author), Deloukas Panos (Author), Alvarez Victoria (Author), Coto Eliecer (Author), Barber Rachel (Author), Kehoe Patrick G (Author), Brown Kristelle (Author), Wilcock Gordon K (Author), Lehmann Michael G (Author), Belbin Olivia (Author), Cortina-Borja Mario (Author), Hammond Naomi (Author), Warden Donald R (Author), Combarros Onofre (Author), Schuur Maaike (Author), Aulchenko Yurii S (Author), Ikram M Arfan (Author), Breteler Monique M (Author), van Duijn Cornelia M (Author), Morgan Kevin (Author), Smith A David (Author), Lehmann Donald J (Author)
• Format: Book
• Published: BMC, 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Interactions have been reported betwee...