Calycosin as a Novel PI3K Activator Reduces Inflammation and Fibrosis in Heart Failure Through AKT-IKK/STAT3 Axis

• Main Authors: Xiaoping Wang (Author), Weili Li (Author), Yawen Zhang (Author), Qianbin Sun (Author), Jing Cao (Author), NanNan Tan (Author), Shuangjie Yang (Author), Linghui Lu (Author), Qian Zhang (Author), Peng Wei (Author), Xiao Ma (Author), Wei Wang (Author), Yong Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF) progression. Calycosin (Cal) is the major active component of Astragalus mongholicus Bunge and has been reported to have therapeutic effects on the cardiac dysfunction after myocardial infarction. However, wh...