Preparation of Topical Itraconazole with Enhanced Skin/Nail Permeability and In Vivo Antifungal Efficacy against Superficial Mycosis

• Main Authors: Laxman Subedi (Author), Seung-Yub Song (Author), Saurav Kumar Jha (Author), Sung-Ho Lee (Author), Rudra Pangeni (Author), Kyo-Tan Koo (Author), Beum Joon Kim (Author), Seung-Sik Cho (Author), Jin Woo Park (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a stable and highly skin-permeable topical delivery system for itraconazole (ITZ) was designed to provide effective treatment against superficial mycosis. Herein, ITZ was incorporated into a solution composed of ethanol, benzyl alcohol, hydrochloric acid, Transcutol P, and cyclomethic...