Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways

• Main Authors: Cintia Scucuglia Heluany (Author), Paula Barbim Donate (Author), Ayda Henriques Schneider (Author), André Luis Fabris (Author), Renan Augusto Gomes (Author), Isadora Maria Villas-Boas (Author), Denise Vilarinho Tambourgi (Author), Tarcilia Aparecida da Silva (Author), Gustavo Henrique Goulart Trossini (Author), Giovanna Nalesso (Author), Eduardo Lani Volpe Silveira (Author), Fernando Queiroz Cunha (Author), Sandra Helena Poliselli Farsky (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) development is strongly associated with cigarette smoke exposure, which activates the aryl hydrocarbon receptor (AhR) as a trigger for Th17 inflammatory pathways. We previously demonstrated that the exposure to hydroquinone (HQ), one of the major compounds of cigarette tar,...