Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis

• Main Authors: Jan Spaas (Author), Richie P. Goulding (Author), Charly Keytsman (Author), Lena Fonteyn (Author), Jack vanHorssen (Author), Richard T. Jaspers (Author), Bert O. Eijnde (Author), Rob C.I. Wüst (Author)
• Format: Bog
• Udgivet: Wiley, 2022-10-01T00:00:00Z.
• Fag: article
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Abstract Background Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system and pe...