Disturbance of the Warburg effect by dichloroacetate and niclosamide suppresses the growth of different sub-types of malignant pleural mesothelioma in vitro and in vivo

• Main Authors: Sze-Kwan Lam (Author), Sheng Yan (Author), Joyce Sze-Man Lam (Author), Yuqian Feng (Author), Mahjabin Khan (Author), Caoyang Chen (Author), Frankie Chi-Fat Ko (Author), James Chung-Man Ho (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Inhalation of asbestos fibers is the most common cause of malignant pleural mesothelioma (MPM). In 2004, the United States Food and Drug Administration approved a combination of cisplatin with pemetrexed to treat unresectable MPM. Nonetheless novel treatment is urgently needed. The objec...