Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug-drug interaction

• Hauptverfasser: Luna Prieto Garcia (Verfasst von), Anna Lundahl (Verfasst von), Christine Ahlström (Verfasst von), Anna Vildhede (Verfasst von), Hans Lennernäs (Verfasst von), Erik Sjögren (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2022-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Physiologically‐based pharmacokinetic (PBPK) models have an important role in drug discovery/development and decision making in regulatory submissions. This is facilitated by predefined PBPK platforms with user‐friendly graphical interface, such as Simcyp and PK‐Sim. However, evaluations of...