Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug-drug interaction

Abstract Physiologically‐based pharmacokinetic (PBPK) models have an important role in drug discovery/development and decision making in regulatory submissions. This is facilitated by predefined PBPK platforms with user‐friendly graphical interface, such as Simcyp and PK‐Sim. However, evaluations of...

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Main Authors: Luna Prieto Garcia (Author), Anna Lundahl (Author), Christine Ahlström (Author), Anna Vildhede (Author), Hans Lennernäs (Author), Erik Sjögren (Author)
Format: Book
Published: Wiley, 2022-09-01T00:00:00Z.
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