Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug-drug interaction

• Auteurs principaux: Luna Prieto Garcia (Auteur), Anna Lundahl (Auteur), Christine Ahlström (Auteur), Anna Vildhede (Auteur), Hans Lennernäs (Auteur), Erik Sjögren (Auteur)
• Format: Livre
• Publié: Wiley, 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Physiologically‐based pharmacokinetic (PBPK) models have an important role in drug discovery/development and decision making in regulatory submissions. This is facilitated by predefined PBPK platforms with user‐friendly graphical interface, such as Simcyp and PK‐Sim. However, evaluations of...