Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats

• मुख्य लेखकों: Tae Hwan Kim (लेखक), Subindra Kazi Thapa (लेखक), Da Young Lee (लेखक), Seung Eun Chung (लेखक), Jun Young Lim (लेखक), Hyeon Myeong Jeong (लेखक), Chang Ho Song (लेखक), Youn-Woong Choi (लेखक), Sang-Min Cho (लेखक), Kyu-Yeol Nam (लेखक), Won-Ho Kang (लेखक), Soyoung Shin (लेखक), Beom Soo Shin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2018-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

This study examined the effects of esomeprazole on aceclofenac pharmacokinetics and gastrointestinal complications in rats. Aceclofenac alone, or in combination with esomeprazole, was orally administered to male Sprague-Dawley rats. Plasma concentrations of aceclofenac, its major metabolite diclofen...