Pharmacokinetics and Anti-Gastric Ulceration Activity of Oral Administration of Aceclofenac and Esomeprazole in Rats

• Main Authors: Tae Hwan Kim (Author), Subindra Kazi Thapa (Author), Da Young Lee (Author), Seung Eun Chung (Author), Jun Young Lim (Author), Hyeon Myeong Jeong (Author), Chang Ho Song (Author), Youn-Woong Choi (Author), Sang-Min Cho (Author), Kyu-Yeol Nam (Author), Won-Ho Kang (Author), Soyoung Shin (Author), Beom Soo Shin (Author)
• Format: Book
• Published: MDPI AG, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study examined the effects of esomeprazole on aceclofenac pharmacokinetics and gastrointestinal complications in rats. Aceclofenac alone, or in combination with esomeprazole, was orally administered to male Sprague-Dawley rats. Plasma concentrations of aceclofenac, its major metabolite diclofen...