T-cell memory responses elicited by yellow fever vaccine are targeted to overlapping epitopes containing multiple HLA-I and -II binding motifs.

• Main Authors: Andréa Barbosa de Melo (Author), Eduardo J M Nascimento (Author), Ulisses Braga-Neto (Author), Rafael Dhalia (Author), Ana Maria Silva (Author), Mathias Oelke (Author), Jonathan P Schneck (Author), John Sidney (Author), Alessandro Sette (Author), Silvia M L Montenegro (Author), Ernesto T A Marques (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The yellow fever vaccines (YF-17D-204 and 17DD) are considered to be among the safest vaccines and the presence of neutralizing antibodies is correlated with protection, although other immune effector mechanisms are known to be involved. T-cell responses are known to play an important role modulatin...