Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy

• Autori principali: Anna Lethicia L. Oliveira (Autore), Gisele G. L. Santos (Autore), Renan F. Espirito-Santo (Autore), Gessica Sabrina A. Silva (Autore), Afrânio F. Evangelista (Autore), Daniela N. Silva (Autore), Milena B. P. Soares (Autore), Cristiane Flora Villarreal (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2021-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Painful neuropathy is a common adverse effect of oxaliplatin (OXL), a platinum-derivative chemotherapeutic agent. Oxidative stress and mitochondrial dysfunction are key factors contributing to the development of OXL-induced peripheral neuropathy (OIPN). Based on the antioxidant and antinociceptive p...