Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy

• Main Authors: Anna Lethicia L. Oliveira (Author), Gisele G. L. Santos (Author), Renan F. Espirito-Santo (Author), Gessica Sabrina A. Silva (Author), Afrânio F. Evangelista (Author), Daniela N. Silva (Author), Milena B. P. Soares (Author), Cristiane Flora Villarreal (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Painful neuropathy is a common adverse effect of oxaliplatin (OXL), a platinum-derivative chemotherapeutic agent. Oxidative stress and mitochondrial dysfunction are key factors contributing to the development of OXL-induced peripheral neuropathy (OIPN). Based on the antioxidant and antinociceptive p...