A Dual Role of P53 in Regulating Colistin-Induced Autophagy in PC-12 Cells

• Main Authors: Ziyin Lu (Author), Chunli Chen (Author), Zhiyong Wu (Author), Yusong Miao (Author), Ishfaq Muhammad (Author), Liangjun Ding (Author), Erjie Tian (Author), Wanjun Hu (Author), Huilin Ni (Author), Rui Li (Author), Bo Wang (Author), Jichang Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to investigate the mechanism of p53 in regulating colistin-induced autophagy in PC-12 cells. Importantly, cells were treated with 125 μg/ml colistin for 12 and 24 h after transfection with p53 siRNA or recombinant plasmid. The hallmarks of autophagy and apoptosis were examined by re...