Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses mRNA capping to evade the human immune system. The cap formation is performed by the SARS-CoV-2 mRNA cap methyltransferases (MTases) nsp14 and nsp16, which are emerging targets for the development of broad-spectrum antiviral agent...

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Main Authors: Raitis Bobrovs (Author), Iveta Kanepe (Author), Nauris Narvaiss (Author), Liene Patetko (Author), Gints Kalnins (Author), Mihails Sisovs (Author), Anna L. Bula (Author), Solveiga Grinberga (Author), Martins Boroduskis (Author), Anna Ramata-Stunda (Author), Nils Rostoks (Author), Aigars Jirgensons (Author), Kaspars Tars (Author), Kristaps Jaudzems (Author)
Format: Book
Published: MDPI AG, 2021-11-01T00:00:00Z.
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