Effect of eugenol on cytochrome P450 1A2, 2C9, 2D6, and 3A4 activity in human liver microsomes

• मुख्य लेखकों: Naif Fahad M. Alharbi (लेखक), Abdul Ahad (लेखक), Yousef A. Bin Jardan (लेखक), Fahad I. Al-Jenoobi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

This study aimed to provide an understanding of the influence of eugenol on CYP1A2, 2C9, 2D6, and 3A4 in human liver microsomes (HLM). Specific substrate for CYP1A2, 2C9, 2D6, and 3A4 were incubated in HLM with or without eugenol. The formation of their respective metabolites was assessed with HPLC...