Development of a UPLC-MS/MS method for the determination of lacosamide and its metabolite and its application to drug-drug interaction

• Main Authors: Jie Chen (Author), Yuxin Shen (Author), Hailun Xia (Author), Xiaohai Chen (Author), Ren-Ai Xu (Author), Guanyang Lin (Author), Gexin Dai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lacosamide, a third-generation novel antiepileptic drug, was first approved in 2008 as an adjunct to partial seizures. In 2014, the U.S. Food and Drug Administration (FDA) approved it as a single agent for partial seizures. Since epilepsy is a chronic condition, most patients need long-term antiepil...