Optimized Liposomal Delivery of Bortezomib for Advancing Treatment of Multiple Myeloma

• Main Authors: Chi Zhang (Author), Jimmy Chun-Tien Kuo (Author), Yirui Huang (Author), Yingwen Hu (Author), Lan Deng (Author), Bryant C. Yung (Author), Xiaobin Zhao (Author), Zhongkun Zhang (Author), Junjie Pan (Author), Yifan Ma (Author), Robert J. Lee (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bortezomib (BTZ), a boronic acid-derived proteasome inhibitor, is commonly employed in treating multiple myeloma (MM). However, the applications of BTZ are limited due to its poor stability and low bioavailability. Herein, we develop an optimized liposomal formulation of BTZ (L-BTZ) by employing a r...