Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

• Prif Awduron: Carlotta Granchi (Awdur), Isabella Caligiuri (Awdur), Eleonora Bertelli (Awdur), Giulio Poli (Awdur), Flavio Rizzolio (Awdur), Marco Macchia (Awdur), Adriano Martinelli (Awdur), Filippo Minutolo (Awdur), Tiziano Tuccinardi (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Pynciau: article
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Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors are reported in literature; however, many of them are characterised by an irreversible mechanism of action and thi...