Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

• Main Authors: Carlotta Granchi (Author), Isabella Caligiuri (Author), Eleonora Bertelli (Author), Giulio Poli (Author), Flavio Rizzolio (Author), Marco Macchia (Author), Adriano Martinelli (Author), Filippo Minutolo (Author), Tiziano Tuccinardi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors are reported in literature; however, many of them are characterised by an irreversible mechanism of action and thi...