Pharmacogenetics-Informed Pharmacometabolomics as an Innovative Approach to Assessing the Safety and Risk of Pharmacotherapy with Valproic Acid

• Главные авторы: N. A. Shnayder (Автор), V. V. Grechkina (Автор), V. V. Arkhipov (Автор), R. F. Nasyrova (Автор)
• Формат: ‌
• Опубликовано: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», 2023-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Scientific relevance. Valproic acid (VPA) is a psychotropic medicinal product, which may be associated with serious adverse drug reactions (ADRs). While pharmacogenetics and pharmacometabolomics can significantly affect the safety of valproates, there are no unified approaches to predicting, prevent...