Essentiality of CTNNB1 in Malignant Transformation of Human Embryonic Stem Cells under Long-Term Suboptimal Conditions

• Main Authors: Jie Liu (Author), Sicong Zeng (Author), Yang Wang (Author), Juan Yu (Author), Qi Ouyang (Author), Liang Hu (Author), Di Zhou (Author), Ge Lin (Author), Yi Sun (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human embryonic stem cells (hESCs) gradually accumulate abnormal karyotypes during long-term suboptimal culture, which hinder their application in regenerative medicine. Previous studies demonstrated that the activation of CTNNB1 might be implicated in this process. Hence, the hESC line with stably...