Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations

• প্রধান লেখক: Chaozhuang Shen (লেখক), Wenxin Shao (লেখক), Wenhui Wang (লেখক), Hua Sun (লেখক), Xiaohu Wang (লেখক), Kuo Geng (লেখক), Xingwen Wang (লেখক), Haitang Xie (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2023-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Levetiracetam (LEV) is an anti‐epileptic drug approved for use in various populations. The pharmacokinetic (PK) behavior of LEV may be altered in the elderly and patients with renal and hepatic impairment. Thus, dosage adjustment is required. This study was conducted to investigate how the...