Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations

• Hauptverfasser: Chaozhuang Shen (Verfasst von), Wenxin Shao (Verfasst von), Wenhui Wang (Verfasst von), Hua Sun (Verfasst von), Xiaohu Wang (Verfasst von), Kuo Geng (Verfasst von), Xingwen Wang (Verfasst von), Haitang Xie (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2023-07-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Levetiracetam (LEV) is an anti‐epileptic drug approved for use in various populations. The pharmacokinetic (PK) behavior of LEV may be altered in the elderly and patients with renal and hepatic impairment. Thus, dosage adjustment is required. This study was conducted to investigate how the...