Physiologically based pharmacokinetic modeling of levetiracetam to predict the exposure in hepatic and renal impairment and elderly populations

• Main Authors: Chaozhuang Shen (Author), Wenxin Shao (Author), Wenhui Wang (Author), Hua Sun (Author), Xiaohu Wang (Author), Kuo Geng (Author), Xingwen Wang (Author), Haitang Xie (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Levetiracetam (LEV) is an anti‐epileptic drug approved for use in various populations. The pharmacokinetic (PK) behavior of LEV may be altered in the elderly and patients with renal and hepatic impairment. Thus, dosage adjustment is required. This study was conducted to investigate how the...