Characteristics and genetic analysis of patients suspected with early-onset systemic lupus erythematosus

• Main Authors: Wan-Fang Lee (Author), Wen-Lang Fan (Author), Min-Hua Tseng (Author), Huang-Yu Yang (Author), Jing-Long Huang (Author), Chao-Yi Wu (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Systemic lupus erythematosus (SLE) is rarely diagnosed before 5-years-old. Those with disease onset at a very young age are predicted by a higher genetic risk and a more severe phenotype. We performed whole-exome sequencing to survey the genetic etiologies and clinical manifestat...