Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway

• Main Authors: Kui Chen (Author), Hao-jie Jin (Author), Zi-heng Wu (Author), Bao-fu Zhang (Author), Jun Wu (Author), Zi-yi Huang (Author), Ying-peng Huang (Author), Xin-wu Lu (Author), Xiang-tao Zheng (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Vascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle cells (VSMCs) plays a critical role in diabetes-related VC. Mitophagy can inhibit phenotype switching in VSMCs. This study aimed to investiga...