Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

• Main Authors: Xiang Wang (Author), Xinxin Chen (Author), Wenqian Zhou (Author), Hongbo Men (Author), Terigen Bao (Author), Yike Sun (Author), Quanwei Wang (Author), Yi Tan (Author), Bradley B. Keller (Author), Qian Tong (Author), Yang Zheng (Author), Lu Cai (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy (DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model. Advanced glycation end-products (AGEs), an important pathogenic factor of DCM, were found to induc...