Blocking iNOS and endoplasmic reticulum stress synergistically improves insulin resistance in mice

• Main Authors: Tamires M. Zanotto (Author), Paula G.F. Quaresma (Author), Dioze Guadagnini (Author), Lais Weissmann (Author), Andressa C. Santos (Author), Juliana F. Vecina (Author), Kelly Calisto (Author), Andrey Santos (Author), Patrícia O. Prada (Author), Mario J.A. Saad (Author)
• Format: Book
• Published: Elsevier, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recent data show that iNOS has an essential role in ER stress in obesity. However, whether iNOS is sufficient to account for obesity-induced ER stress and Unfolded Protein Response (UPR) has not yet been investigated. In the present study, we used iNOS knockout mice to investigate whether...