Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

The pathogenesis of Crohn's disease (CD) involves defects in the innate immune system, impairing responses to microbes. Studies have revealed that mutations NLRP3 are associated with CD. We reported previously that Nlrp3−/− mice were more susceptible to colitis and exhibited reduced colonic IL-...

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Main Authors: Simon A. Hirota (Author), Aito Ueno (Author), Sarah E. Tulk (Author), Helen M. Becker (Author), L. Patrick Schenck (Author), Mireille S. Potentier (Author), Yan Li (Author), Subrata Ghosh (Author), Daniel A. Muruve (Author), Justin A. MacDonald (Author), Paul L. Beck (Author)
Format: Book
Published: Hindawi Limited, 2016-01-01T00:00:00Z.
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